🔬 Ricerca e Sviluppo
Il Centro AMES crede nella ricerca come motore di crescita e progresso. Nella nostra sede di Casalnuovo di Napoli, la divisione Ricerca e Sviluppo è il cuore pulsante dell’innovazione scientifica.
🌍 Collaborazioni e pubblicazioni
Il nostro team partecipa attivamente a progetti di ricerca clinica e di base, pubblica su riviste internazionali e collabora con prestigiosi istituti di ricerca, sia in Italia che all’estero.
🧬 Genetica e biologia molecolare
Lavoriamo per espandere le conoscenze in Genetica Medica e Biologia Molecolare, con l’obiettivo di migliorare costantemente la qualità dei servizi offerti e fornire soluzioni personalizzate e altamente specializzate.
"Conoscere di piĂą per curare meglio."
"La ricerca di oggi è la medicina di domani."
Cliccare su una delle seguenti sezioni per visualizzare il contenuto:
innovativi
🧬 Diagnostica Prenatale e Genetica Riproduttiva
Detection of SRY-positive46,XX male syndrome by the analysis of cell-free fetal DNA via non-invasive prenatal testing
De Falco L. et al., Clin Case Rep. 2019 — DOI: 10.1002/ccr3.2389
Performance of cell-free DNA sequencing-based non-invasive prenatal testing: experience on 36,456 singleton and multiple pregnancies
La Verde M. et al., BMC Med Genomics. 2021 — DOI: 10.1186/s12920-021-00941-y
A Case Report of a Feto-Placental Mosaicism Involving a Segmental Aneuploidy: A Challenge for Genome Wide Screening by Non-Invasive Prenatal Testing of Cell-Free DNA in Maternal Plasma
De Falco L. et al., Genes. 2023 — DOI: 10.3390/genes14030668
Genome-Wide Noninvasive Prenatal Screening in Twin Pregnancies
De Falco L. et al., Genes. 2023 — DOI: 10.3390/genes14050982
cfDNA chromosomal abnormalities derived from clonal hematopoiesis in hematological malignancies
Giudice V. et al., Clin Exp Med. 2024 — DOI: 10.1007/s10238-024-01313-3
Pentasomy X Detected by Plasma Cell-Free DNA and Karyotype Analysis
De Falco L. et al., Diagnostics. 2022 — DOI: 10.3390/diagnostics12071591
Discordance between NIPT and amniocentesis resulting in mosaicism of trisomy 21
Feresin A. et al., Front Genet. 2022 — DOI: 10.3389/fgene.2022.982508
Inherited Unbalanced Reciprocal Translocation in a Fetus Revealed by cffDNA Testing
Ardisia C. et al., Genes. 2024 — DOI: 10.3390/genes15111464
Editorial: Unravelling the basis of non-invasive prenatal screening results
De Falco L. et al., Front Genet. 2023 — DOI: 10.3389/fgene.2023.1247764
Trisomy 21 with Maternally Inherited Balanced Translocation (15q;22q)
De Falco A. et al., Cells. 2024 — DOI: 10.3390/cells13131078
🧪 Oncologia - Tumori Colorettali e Gastrointestinali
KRAS p.G12C Mutation in Metastatic Colorectal Cancer: Prognostic Implications and Advancements in Targeted Therapies
Ottaiano A. et al., Cancers. 2023 — DOI: 10.3390/cancers15143579
High Tumor Mutational Burden Assessed through NGS in MSS Colon Cancer
Di Mauro A. et al., J Transl Med. 2024 — DOI: 10.1186/s12967-024-05927-9
Metastatic Colorectal Cancer and Type 2 Diabetes: Prognostic and Genetic Interactions
Ottaiano A. et al., Mol Oncol. 2022 — DOI: 10.1002/1878-0261.13122
The Tumor Dynamism Is the Dark Matter of the NGS Galaxy
Ottaiano A. et al., Cancers. 2021 — DOI: 10.3390/cancers13215476
Oligo-Metastatic Disease in Oncology: Exploring the Limits and the Potential of Genetic Assessment
Santorsola M. et al., Genes. 2023 — DOI: 10.3390/genes14122131
From Chaos to Opportunity: Decoding Cancer Heterogeneity for Enhanced Treatment Strategies
Ottaiano A. et al., Biology. 2023 — DOI: 10.3390/biology12091183
Oligo-Metastatic Cancers: Putative Biomarkers, Emerging Challenges and New Perspectives
Ottaiano A. et al., Cancers. 2023 — DOI: 10.3390/cancers15061827
Clinical and Genetic Drivers of Oligo-Metastatic Disease in Colon Cancer
Ottaiano A. et al., Neoplasia. 2025 — DOI: 10.1016/j.neo.2024.101111
Mutational Landscape and Tumor Immune-Microenvironment in Liver Oligo-Metastatic CRC
Ottaiano A. et al., Cancers. 2020 — DOI: 10.3390/cancers12103073
Radiotherapy-Induced Immunologic and Genetic Effects in CRC Oligo-Metastatic Patients
Ottaiano A. et al., Cancers. 2021 — DOI: 10.3390/cancers13164236
Microsatellite Status Detection in Gastrointestinal Cancers
Zito Marino F. et al., Cancers. 2022 — DOI: 10.3390/cancers14092204
The Prognostic Role of p53 Mutations in Metastatic Colorectal Cancer
Ottaiano A. et al., Crit Rev Oncol Hematol. 2023 — DOI: 10.1016/j.critrevonc.2023.104018
Hypertension, Type 2 Diabetes, Obesity, and p53 Mutations Correlate with Survival
Ottaiano A. et al., Front Med. 2023 — DOI: 10.3389/fmed.2023.1091634
Genetic Landscape of Colorectal Cancer Patients with Tumor Shrinkage during SARS-CoV-2 Infection
Ottaiano A. et al., Ther Adv Med Oncol. 2022 — DOI: 10.1177/17588359221138388
Characterization of KRAS Mutational Regression in Oligometastatic Patients
Ottaiano A. et al., Front Immunol. 2022 — DOI: 10.3389/fimmu.2022.898561
Vitamin D Deficiency and Tumor Aggressiveness in Neuroendocrine Tumors
Altieri B. et al., Endocrine. 2022 — DOI: 10.1007/s12020-021-02869-w
Clinical and Molecular Characteristics of Rare Malignant Tumors of Colon and Rectum
Ottaiano A. et al., Biology. 2022 — DOI: 10.3390/biology11020267
Emerging Treatment Approaches for Triple-Negative Breast Cancer
Capuozzo M. et al., Med Oncol. 2023 — DOI: 10.1007/s12032-023-02257-6
Vitamin D Deficiency and Tumor Aggressiveness in Gastroenteropancreatic NETs
Altieri B. et al., Endocrine. 2022 — DOI: 10.1007/s12020-021-02869-w
Genetic Regressive Trajectories in Colorectal Cancer: A New Hallmark of Oligo-Metastatic Disease?
Ottaiano A. et al., Transl Oncol. 2021 — DOI: 10.1016/j.tranon.2021.101131
KRAS Mutational Regression Associated with Oligo-Metastatic Status
Ottaiano A. et al., Front Oncol. 2021 — DOI: 10.3389/fonc.2021.632962
🧫 Malattie Rare e Genetica Clinica
Case-mix experience for fragile X syndrome molecular diagnosis
Esposito G. et al., Clin Chim Acta. 2013 — DOI: 10.1016/j.cca.2012.12.021
Prenatal molecular diagnosis of inherited neuromuscular diseases
Esposito G. et al., Clin Chem Lab Med. 2013 — DOI: 10.1515/cclm-2013-0209
Combined PTPN11 and MYBPC3 Gene Mutations in Noonan Syndrome
Caiazza M. et al., Genes. 2020 — DOI: 10.3390/genes11080947
MED12 Mutation in Two Families with X-Linked Ohdo Syndrome
Rocchetti L. et al., Genes. 2021 — DOI: 10.3390/genes12091328
Detection of 46, XY Disorder of Sex Development (DSD)...
De Falco L. et al., Genes. 2021 — DOI: 10.3390/genes12121890
Vitamin D deficiency and tumor aggressiveness in neuroendocrine tumors
Altieri B. et al., Endocrine. 2021 — DOI: 10.1007/s12020-021-02869-w
Vitamin D deficiency and tumor aggressiveness in gastroenteropancreatic neuroendocrine tumors
Altieri B. et al., Endocrine. 2022 — DOI: 10.1007/s12020-021-02869-w
Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review
Ronchi A. et al., Int J Mol Sci. 2023 — DOI: 10.3390/ijms24076204
🧍‍♂️ Immunologia e COVID-19
Origin, Genetic Variation and Molecular Epidemiology of SARS-CoV-2 Strains Circulating in Sardinia
Rocchigiani A.M. et al., Viruses. 2023 — DOI: 10.3390/v15020277
Genetic landscape of colorectal cancer patients manifesting tumor shrinkage during SARS-Cov-2 infection
Ottaiano A. et al., Ther Adv Med Oncol. 2022 — DOI: 10.1177/17588359221138388
PD-L1 Overexpression in Lungs of Subjects Who Died from COVID-19
Ronchi A. et al., Crit Rev Eukaryotic Gene Expr. 2022
Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review
Ronchi A. et al., Int J Mol Sci. 2023 — DOI: 10.3390/ijms24076204
🧍‍♂️ Immunologia e COVID-19
Origin, Genetic Variation and Molecular Epidemiology of SARS-CoV-2 Strains Circulating in Sardinia
Rocchigiani A.M. et al., Viruses. 2023 — DOI: 10.3390/v15020277
Genetic landscape of colorectal cancer patients manifesting tumor shrinkage during SARS-Cov-2 infection
Ottaiano A. et al., Ther Adv Med Oncol. 2022 — DOI: 10.1177/17588359221138388
PD-L1 Overexpression in Lungs of Subjects Who Died from COVID-19
Ronchi A. et al., Crit Rev Eukaryotic Gene Expr. 2022
Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review
Ronchi A. et al., Int J Mol Sci. 2023 — DOI: 10.3390/ijms24076204
🦠Virologia e Malattie Animali
Dual African Swine Fever Virus Infection in Sardinia
Fiori M.S. et al., Viruses. 2021 — DOI: 10.3390/v13101994
First Genomic Evidence of Dual African Swine Fever Virus Infection: Case Report from Sardinia
Fiori M.S. et al., Viruses. 2021 — DOI: 10.3390/v13112145
A Deeper Insight into Evolutionary Patterns and Phylogenetic History of ORF Virus
Coradduzza E. et al., Viruses. 2022 — DOI: 10.3390/v14071473
Origin, Genetic Variation and Molecular Epidemiology of SARS-CoV-2 Strains Circulating in Sardinia
Rocchigiani A.M. et al., Viruses. 2023 — DOI: 10.3390/v15020277
📡 Approcci diagnostici innovativi
Low-Cost GNSS Reference Station – The GREAT Project
Curone D. et al., Sensors. 2023 — DOI: 10.3390/s23136032
Application of HPV-DNA Test on Salivary Gland FNA Cytology Samples
Cozzolino I. et al., Diagn Cytopathol. 2025 — DOI: 10.1002/dc.25425
Serum miRNA Signature for Early Detection of Laryngeal Carcinoma
Falco M. et al., J Transl Med. 2024 — DOI: 10.1186/s12967-024-05385-3
Emerging Treatment Approaches for Triple-Negative Breast Cancer
Capuozzo M. et al., Med Oncol. 2023 — DOI: 10.1007/s12032-023-02257-6
Endurant Stent Graft for Abdominal Aortic Aneurysm: 14-Year Experience
Accarino G. et al., J Clin Med. 2024 — DOI: 10.3390/jcm13092589
Innovative Drug Modalities for Advanced Prostate Cancer
Capuozzo M. et al., Diseases. 2024 — DOI: 10.3390/diseases12050087
Self-Assembling Nanoparticles for Delivery of miR-603 and miR-221 in Glioblastoma
Abate M. et al., J Control Release. 2025 — DOI: 10.1016/j.jconrel.2024.11.039
Ames ha preso parte dal 2018 al 2020, in qualitĂ di capofila, al progetto ANDROKIT. Il progetto di ricerca è stato svolto grazie alla collaborazione fra AMES, UniversitĂ di Napoli Federico II ed il Centro Diagnostico Basile. Il progetto mira allo sviluppo ed alla validazione clinica di strumenti diagnostici innovativi, non invasivi per l’inquadramento clinico e la selezione dell’approccio terapeutico per l’infertilitĂ maschile ed è stato cofinanziato dall’Unione Europea, dallo Stato Italiano e dalla Regione Campania nell’ambito del POR Campania FESR 2014-2020 con Avviso Pubblico per il sostegno alle imprese campane nella realizzazione di studi di fattibilitĂ (Fase 1) e progetti di trasferimento tecnologico (Fase 2) coerenti con la RIS3. CUP B13D18000140007